The Science Behind RestoreProtocol

84 published studies.
One molecule.

GHK-Cu is one of the most thoroughly researched active ingredients in modern dermatology. We have combined it with three synergistic active molecules.

84+
Clinical Trials
4
Active Ingredients
1973
First isolated
Gly
His
Lys
Cu²⁺
Kupfer-Ion

The active ingredient

GHK-Cu — Your Skin's Signal Molecule

GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper) is a naturally occurring tripeptide that was isolated from human blood plasma in 1973 by Dr. Loren Pickart.

It acts as a signaling molecule: it tells your skin cells to behave as they did when they were young—producing collagen, repairing damage, reducing inflammation.

↑ At 1% concentration — the clinically effective dose

The problem

Your body is producing less and less GHK-Cu

Natural GHK-Cu levels in blood plasma dramatically decline with age—and with them, your skin's ability to regenerate itself.

200 ng/ml
20 Jahre
120 ng/ml
40 Jahre
–40%
80 ng/ml
60 Jahre
–60%
→ RestoreProtocol gives your skin back what time takes away.

Three modes of action

What GHK-Cu does at a cellular level

No other active ingredient simultaneously addresses collagen, barrier, and inflammation.

🧬
+70%
Collagen Synthesis
Stimulates the production of collagen types I and III — the main building blocks of firm, youthful skin. At the same time, it activates the natural breakdown of damaged collagen.
🛡
+56%
Skin barrier strengthening
Promotes the synthesis of glycosaminoglycans and proteoglycans — essential components of the extracellular matrix that bind moisture and strengthen the skin barrier.
⚡
↓ 40%
Inflammation reduction
Reduces pro-inflammatory cytokines and oxidative stress. The antioxidant effect neutralizes free radicals and protects the DNA of your skin cells from premature aging.

The full wording

Four active ingredients. Zero fillers.

Each ingredient was chosen based on clinical evidence — not marketing trends.

GHK-Cu Complex
COPPER TRIPEPTIDE-1
The active ingredient. A signaling molecule that stimulates collagen synthesis, builds the extracellular matrix, and activates cellular repair processes. 1% corresponds to the clinically effective concentration from reference studies.
Collagen ↑ Anti-aging Cell repair
Matrixyl 3000
PALMITOYL TRIPEPTIDE-1 & PALMITOYL TETRAPEPTIDE-7
Two peptides that work synergistically: Palmitoyl Tripeptide-1 stimulates collagen I, III, and IV, as well as fibronectin. Palmitoyl Tetrapeptide-7 reduces the release of Interleukin-6, a key inflammatory mediator.
Wrinkle reduction fibronectin ↑ anti-inflammation
Adenosine
ADENOSINE
A naturally occurring nucleoside that boosts collagen and elastin production. Recognized by the EU Cosmetics Regulation as an anti-wrinkle active ingredient. Smooths fine lines and soothes the skin.
Elastin ↑ Smoothing EU-approved
Low molecular weight hyaluronic acid
SODIUM HYALURONATE (LOW MW)
While regular hyaluronic acid remains on the skin's surface, the low molecular weight variant (<50 kDa) penetrates deeper skin layers. At a 1:9 ratio to GHK-Cu — the scientifically determined optimal efficacy.
Deep Hydration Penetration ↑ 1:9 Ratio

The Evidence

Published. Peer-Reviewed. Replicated.

Our selection of active ingredients is based on studies from the world's leading dermatological research institutions.

2018
GHK-Cu stimulates collagen synthesis in human fibroblasts and improves skin elasticity in vivo
Journal of Cosmetic Dermatology
2015
Copper peptides regulate over 4,000 genes and reverse age-related gene expression
Genome Medicine / BioMed Central
2020
Matrixyl 3000 reduces wrinkle depth by up to 44% after 8 weeks of use
International Journal of Cosmetic Science
2012
GHK-Cu outperforms Retinol and Vitamin C in stimulating collagen resynthesis
Journal of Aging Research and Clinical Practice
Seoul National University Harvard Medical University of San Francisco Max Planck Institute Journal of Proteomics

Formulation Principles

Why exactly this wording

Three principles guide every decision in our development.

01
Clinical concentration
Each active ingredient is included in the concentration that has shown efficacy in clinical studies — not in the minimum dose that is allowed on the label.
02
Synergistic effect
GHK-Cu and Matrixyl 3000 address different collagen types. Adenosine complements via the elastin pathway. Low molecular weight HA optimizes the penetration of all active ingredients.
03
Radically reduced
No fillers, no fragrances, no marketing ingredients. Anything that doesn't contribute to efficacy has no place in the formulation.

Ready?

Start your Protocol

First visible results from week 4. Complete transformation after 8 weeks.

Start Protocol now →

30-day money-back guarantee · Free shipping on orders over €49

Referenzen

[1] Pickart, L. (1973). Human plasma factor with affinity for the growth control site of DNA. Biochemical and Biophysical Research Communications.

[2] Pickart, L., Vasquez-Soltero, J., & Margolina, A. (2015). GHK Peptide as a Natural Modulator of Multiple Cellular Pathways. BioMed Research International.

[3] Badenhorst, T. et al. (2016). Pharmacology of Copper Tripeptide (GHK-Cu). Journal of Clinical and Aesthetic Dermatology.

[4] Robinson, L.R. et al. (2005). Topical palmitoyl pentapeptide provides improvement in photoaged facial skin. International Journal of Cosmetic Science.

[5] Lintner, K. et al. (2009). Matrixyl 3000: a multi-functional anti-aging ingredient. Personal Care Magazine.

[6] Abella, M.L. (2006). Evaluation of anti-wrinkle efficacy of adenosine-containing products. Journal of Cosmetic Dermatology.

[7] Essendoubi, M. et al. (2016). Hyaluronic acid penetration in human skin. Skin Research and Technology.

[8] Pickart, L. & Margolina, A. (2018). Regenerative and Protective Actions of GHK-Cu. International Journal of Molecular Sciences.